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M94A2408.TXT
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1994-10-25
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Document 2408
DOCN M94A2408
TI Natural history of vertically acquired HIV infection.
DT 9412
AU Giaquinto C; De Rossi A; Pagliaro A; Cozzani S; Ruga E; Mazza A;
Giacomelli A; Tessarotto L; Oletto S; Dep. of Pediatrics, Univ. of
Padova, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):310 (abstract no. PC0170). Unique
Identifier : AIDSLINE ICA10/94370167
AB OBJECTIVES: To study the natural history of pediatric HIV infection.
METHODS: All children born to seropositive mothers were identified and
followed from birth clinically, immunologically and virologically (PCR
and virus culture) every 4-6 weeks in the first 6 months, and 6 monthly
there after. Children were defined as infected if symptomatic or if the
virus was identified in the blood on 2 or more occasions at least apart.
RESULTS: By January 1994, 246 children have been enrolled; 173 since
birth and 73 after birth, 78% were born to drug user mothers, 22% to
mothers with seropositive partners. The mean length of follow up of
patients enrolled at birth was 39 months. At 6 months children followed
up from birth were classified as follows: 28 infected, 133 uninfected,
12 indeterminate. One child although seronegative had evidence of viral
genome on repeated virus culture and PCR. The transmission rate
calculated at 6 months is 16% (C.I. 10.9-21.7) and do not differ fron
that reported by European collaborative Study. Children followed up from
birth have AIDS (CDC classification), among these group 10 presented
encephalopathy (American Academy of Neurology AIDS Task Force). Several
virological factors (viral phenotypes, viral burden etc.) were
prognostically correlated with the outcome of infection.
DE Female Follow-Up Studies Human HIV Infections/DIAGNOSIS/*TRANSMISSION
HIV Seropositivity Infant Infant, Newborn Pregnancy *Pregnancy
Complications, Infectious MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).